Material Safety Data Sheet: 1-Bromo-3-Chloropropane

Identification

Product Name: 1-Bromo-3-Chloropropane
Synonyms: 3-Chloropropyl bromide
CAS Number: 109-70-6
Molecular Formula: C3H6BrCl
Molecular Weight: 157.44 g/mol
Use: Specialty chemical for organic synthesis, intermediate in pharmaceuticals and agrochemicals
Manufacturer/Supplier: Contact details for responsible party should be included in local MSDS copy
Emergency Contact: Local emergency phone numbers, recommended local poison control information

Hazard Identification

Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin irritation
GHS Label Elements: Hazard pictograms: Skull and crossbones, exclamation mark
Signal Word: Danger
Hazard Phrases: Toxic if swallowed, causes skin and eye irritation, may cause respiratory irritation, harmful if inhaled, suspected of damaging fertility or the unborn child
Precautionary Statements: Avoid breathing vapors or mist, wear protective gloves and clothing, wash skin thoroughly after handling, avoid release to the environment, use only outdoors or in a well-ventilated area, do not eat, drink or smoke when using this product

Composition / Information on Ingredients

Chemical Name: 1-Bromo-3-Chloropropane
Synonyms: 3-Chloropropyl bromide
CAS Number: 109-70-6
Concentration: 98-100%
Impurities: Minor organic halides, typically <1%

First Aid Measures

General advice: Get medical attention immediately. Show this safety data sheet to the doctor.
Inhalation: Move person to fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration.
Skin contact: Immediately wash area with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present. Continue rinsing.
Ingestion: Do not induce vomiting. Rinse mouth with water, never give anything by mouth to an unconscious person. Seek immediate medical attention.
Symptoms: Burning sensation, coughing, headache, nausea, dizziness, vomiting, skin and eye irritation, possible respiratory issues

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Extinguishing Media: Direct water streams
Hazardous Combustion Products: Hydrogen chloride, hydrogen bromide, phosgene, carbon oxides
Protective Equipment: Wear self-contained breathing apparatus and full firefighting gear
Fire/Explosion Hazard: Vapors are heavier than air and may travel along the ground to a distant ignition source
Special Procedures: Evacuate area, do not allow water runoff to enter drains or sewers

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, use protective equipment to prevent contact with skin, eyes, and clothing
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid release to the environment, keep away from drains, surface and groundwater
Methods for Clean Up: Absorb liquid with inert material such as sand or earth, collect and seal in properly labeled containers for proper disposal, ventilate the area and wash spill area after collection
Emergency Procedures: Isolate hazard area and keep unauthorized personnel away

Handling and Storage

Handling: Use only in well-ventilated areas, avoid contact with skin, eyes, and clothing, do not breathe fumes/vapor, keep away from ignition sources, handle in accordance with established chemical hygiene protocols, wash hands and face after handling
Storage: Store in tightly closed containers in a cool, dry, well-ventilated, fireproof area, away from incompatible substances like strong bases, strong oxidizing agents, and water sources, keep containers tightly sealed and properly labeled

Exposure Controls and Personal Protection

Engineering Controls: Use with adequate ventilation such as chemical fume hood or local exhaust, ensure eyewash stations and safety showers are close to the work station
Eye Protection: Chemical safety goggles conforming to EN166 or equivalent
Skin Protection: Chemical resistant gloves (nitrile, PVC), long-sleeved laboratory coats, aprons
Respiratory Protection: Use NIOSH-approved respirators if ventilation is inadequate or exposure limits are exceeded
Environmental Exposure Controls: Prevent release to public water systems or sewage
Exposure Limits: No specific occupational exposure limits established; minimize exposure by use of control measures

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Sweet, chloroform-like
Boiling Point: 142-145°C
Melting Point: -70°C
Flash Point: 54°C (closed cup)
Auto-ignition Temperature: Not established
Vapor Pressure: 3 mmHg at 20°C
Density: 1.52 g/cm³ at 20°C
Solubility: Insoluble in water; soluble in organic solvents
Partition Coefficient (Log Kow): 2.0 (estimated)
Refractive Index: 1.483-1.487
pH: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: May react with strong oxidizing agents, strong bases
Conditions to Avoid: Heat, open flames, sparks, incompatibles
Incompatible Materials: Water, strong acids, alkali metals, oxidizing and reducing agents, finely divided metals, aluminum
Hazardous Decomposition Products: Hydrogen chloride, hydrogen bromide, phosgene, carbon monoxide, carbon dioxide
Polymerization: Does not occur under normal conditions

Toxicological Information

Acute Toxicity: Oral LD50 (rat): 230 mg/kg, Dermal LD50 (rabbit): No data available, Inhalation LD50 (rat): No data available
Skin Irritation: Causes irritation, possible burns upon prolonged exposure
Eye Irritation: Causes severe irritation, possible corneal injury
Respiratory Sensitization: May cause respiratory tract irritation, coughing, shortness of breath
Carcinogenicity: Not listed as carcinogen by ACGIH, IARC, NTP, OSHA
Reproductive Toxicity: Suspected effects based on animal studies, not fully established in humans
Chronic Effects: Prolonged exposure may affect central nervous system, liver, and kidneys
Symptoms: Headache, dizziness, nausea, skin burns, eye damage, CNS depression
Mutagenicity: Possible mutagenic activity observed in some tests

Ecological Information

Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Not readily biodegradable, persists in the environment
Bioaccumulation Potential: Bioaccumulation possible due to moderate partition coefficient
Mobility in Soil: Moderate mobility, may leach into groundwater
Other Adverse Effects: Avoid release to nature; potential for ozone depletion due to halogenated structure

Disposal Considerations

Waste Treatment Methods: Dispose of this material and its container to hazardous or special waste collection point, incineration preferred method when permitted
Contaminated Packaging: Dispose of as unused product
Precautions: Do not discharge to drains, surface or groundwater, follow all local, regional, national, international guidelines
Additional Notes: Seek assistance from certified disposal contractors, comply with all waste management regulations

Transport Information

UN Number: 2688
UN Proper Shipping Name: 1-Bromo-3-chloropropane
Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Environmental Hazards: Marine pollutant
Special Precautions: Keep away from foodstuffs, feed, and animal food; transport in accordance with all applicable regulations
Labeling Requirements: Toxic, Marine pollutant

Regulatory Information

OSHA: Hazardous chemical under OSHA Hazard Communication Standard
TSCA: Listed on the TSCA inventory
EINECS: 203-697-8
SARA 313: Subject to reporting, see regulations
WHMIS: Classified as toxic, handle as controlled product
State Regulations: Check specific state requirements for use and disposal
Other: Subject to local, national, and international regulations on storage, handling, and transportation of toxic chemicals