Material Safety Data Sheet: Ethyl Bromoacetate

Identification

Product Name: Ethyl Bromoacetate
Chemical Formula: C4H7BrO2
Molecular Weight: 167.01 g/mol
CAS Number: 105-36-2
Synonyms: Bromoacetic acid ethyl ester, ethyl 2-bromoacetate
Recommended Use: Laboratory reagent, synthesis intermediate, pharmaceutical research
Manufacturer: Chemical suppliers and specialized research distributors
Contact Point: Refer to product label for emergency numbers

Hazard Identification

Hazard Classification: Acute toxicity (oral, dermal); serious eye and skin irritant; specific organ toxicity, category 3
GHS Label Elements: Skull and crossbones pictogram, exclamation mark, corrosive symbol
Signal Word: Danger
Hazard Statements: Toxic if swallowed or inhaled; causes severe skin burns and eye damage; may cause respiratory irritation
Precautionary Statements: Avoid skin, eye, and clothing contact; avoid breathing vapors or mists; wear protective gloves, eye protection, and clothing
Potential Health Effects: Inhalation can cause cough, sore throat, dizziness; skin or eye contact causes burns, redness, or severe irritation; ingestion leads to burning pain, abdominal cramps, and vomiting
Environmental Hazards: Harmful to aquatic organisms, may cause long-term effects in the environment

Composition / Information on Ingredients

Component: Ethyl Bromoacetate
Chemical Identity: Ethyl Bromoacetate (C4H7BrO2)
CAS Number: 105-36-2
Concentration: 97%-100%
Impurities: Trace amounts of bromoacetic acid and ethanol esters may be present, concentrations low enough not to alter risk assessment

First Aid Measures

Inhalation: Remove to fresh air immediately; provide oxygen if breathing is difficult; seek medical attention without delay
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with large volumes of water for at least 15 minutes; seek urgent medical care due to risk of burns
Eye Contact: Rinse cautiously with water for several minutes, keeping eyelids open; continue rinsing and remove contact lenses if possible; emergency medical care required
Ingestion: Rinse mouth thoroughly; do not induce vomiting; never give anything by mouth to an unconscious person; seek emergency medical aid
Main Symptoms and Effects: Severe irritation, chemical burns, respiratory difficulty, dizziness, gastrointestinal pain
Protection for First Aiders: Wear chemical-resistant gloves, face shield, and appropriate respiratory protection during rescue

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, alcohol-resistant foam; water spray for small fires
Unsuitable Agents: Avoid direct stream of water, which may spread fire or chemical
Specific Hazards: Releases toxic fumes and corrosive gases (hydrogen bromide, carbon oxides) under fire conditions; sealed containers can rupture due to pressure build-up
Protective Equipment for Firefighters: Full protective gear including self-contained breathing apparatus
Firefighting Instructions: Isolate hazard area, cool containers exposed to flames with water spray, avoid inhaling vapors or fumes, remove unprotected personnel
Fire Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide

Accidental Release Measures

Personal Precautions: Evacuate non-essential personnel; ventilate area; avoid breathing vapors; use suitable protective gear (gloves, goggles, respirator)
Environmental Precautions: Prevent spillage from entering waterways, drains, or soil; notify environmental authorities if contamination occurs
Cleanup Methods: Absorb spills with inert material like sand or vermiculite; place residue in tightly sealed containers for disposal; clean area with copious water and detergent using non-sparking tools
Special Alert: Do not touch or walk through spilled material; provide ventilation; eliminate all ignition sources during cleanup

Handling and Storage

Precautions for Safe Handling: Handle in well-ventilated fume hood; use chemical-resistant gloves and safety eyewear; avoid inhalation or direct contact; do not eat, drink, or smoke where chemical is handled
Storage Conditions: Store in tightly closed amber glass containers, cool, dry, ventilated place protected from light; keep away from heat, ignition sources, strong bases, acids, oxidizing agents
Storage Class: Corrosive substances, segregated from incompatible materials
Special Practices: Label containers clearly, maintain spill kits nearby, inspect regularly for leaks or corrosion, restrict access to trained personnel

Exposure Controls and Personal Protection

Occupational Exposure Limits: No official threshold limit value set by OSHA, ACGIH, or NIOSH; minimize exposure as much as possible
Engineering Controls: Chemical fume hood required; emergency eyewash station and safety shower nearby; local exhaust ventilation
Personal Protective Equipment: Nitrile or butyl rubber gloves, anti-splash chemical goggles, lab coat or chemical-resistant suit, chemical-resistant footwear
Respiratory Protection: Use NIOSH-approved respirators in case of potential vapor formation or insufficient ventilation
Hygiene Measures: Wash hands thoroughly after handling, change contaminated clothing, never reuse contaminated personal protective equipment

Physical and Chemical Properties

Appearance: Colorless to yellowish clear liquid
Odor: Sharp, penetrating
Odor Threshold: Low, but specific value not established
pH: Not applicable in pure form
Melting Point: -52°C
Boiling Point: 159°C
Flash Point: 67°C (closed cup)
Evaporation Rate: Moderate
Flammability: Combustible liquid
Lower/Upper Explosive Limits: Data not provided
Vapor Pressure: 2 mmHg (25°C)
Vapor Density: 5.8 (air = 1)
Relative Density: 1.57 g/cm³
Solubility: Moderately soluble in water, miscible with most organic solvents
Partition Coefficient (log Kow): 1.26
Auto-ignition Temperature: Not established
Decomposition Temperature: Decomposes above 200°C
Viscosity: Not measured precisely

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling; reacts on contact with moisture or bases
Hazardous Reactions: Reacts violently with strong bases, strong oxidizers, and strong acids
Conditions to Avoid: Heat, flames, sparks, exposure to moisture, incompatible chemicals
Incompatible Materials: Strong alkalies, alkali metals, amines, reducing agents, acids, oxidizing agents
Decomposition Products: Hydrogen bromide gas, carbon oxides
Polymerization: No hazardous polymerization expected

Toxicological Information

Acute Toxicity: Harmful if swallowed, inhaled, or in contact with skin; oral LD50 in rats approximately 290 mg/kg
Skin Corrosion/Irritation: Causes severe burns and blistering upon skin exposure
Serious Eye Damage/Irritation: Causes permanent eye injury, pain, vision loss with sufficient exposure
Respiratory Effects: Sore throat, labored breathing, risk of chemical pneumonia if inhaled
Chronic Effects: No comprehensive studies on carcinogenicity, mutagenicity, reproductive risk; long-term exposure may cause lasting tissue damage
Sensitization: No confirmed reports, but caution recommended
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Target Organs: Skin, eyes, respiratory system, gastrointestinal tract

Ecological Information

Ecotoxicity: Harmful to aquatic life, potential to bioaccumulate
Persistence and Degradability: Moderately persistent, may undergo hydrolysis in environment
Bioaccumulative Potential: Estimated low to moderate; log Kow suggests some bioaccumulation risk
Mobility in Soil: Moderate; risk of migration to groundwater if spilled
Aquatic Toxicity: Acute and chronic toxicity data limited, but likely to interfere with aquatic organisms' normal function
Other Adverse Effects: Avoid release to the environment; report large spills to proper authorities

Disposal Considerations

Waste Disposal Methods: Treat as hazardous chemical waste; incinerate in approved facility with proper scrubbing and emission controls; dilute residues must not enter drains
Container Disposal: Triple rinse containers, offer for recycling or reconditioning if permitted, otherwise dispose in compliance with local regulations
Legal Requirements: Follow all local, regional, and national laws covering chemical waste disposal; consult with authorized waste management contractors
Special Instructions: Consult safety officer or environmental department prior to disposal for approval and documentation

Transport Information

UN Number: UN 1916
UN Proper Shipping Name: Ethyl Bromoacetate
Transport Hazard Class: 6.1 (Toxic Substance)
Packing Group: II
Labels Required: Toxic, corrosive
Marine Pollutant: Yes, classified as hazardous for aquatic environments
Special Precautions: Keep separated from food and feedstuffs, ensure containers are intact and properly sealed
Transport by Air: Compliant with IATA regulations for toxic substances
Transport by Land/Sea: IMDG and DOT requirements apply; must carry shipping documents indicating hazard

Regulatory Information

OSHA Hazard Communication: Covered under OSHA hazardous chemical standards
TSCA Inventory: Listed, subject to reporting under TSCA
SARA Title III: Not classified as extremely hazardous but subject to inventory reporting
California Proposition 65: Not listed as a carcinogen or reproductive toxin
REACH Registration: Pre-registration or registration required for quantities above threshold, consult supplier
Other Regulations: WHMIS (Canada): D1B (Toxic), D2B (Irritant); comply with all local, state, and national guidelines
Labelling Needs: Must display applicable hazard symbols and risk phrases on all storage and shipping containers